The US Food and Drug Administration (FDA) took the liberty of approving Repatha, also known as evolocumab injection in order to better help patients who cannot control their cholesterol levels with either one of the treatment options that are now available.
It is a rather daring move since Repatha itself has a good number of side effects which include back pain, flu or upper respiratory tract infection. Also, the application of the injection might lead to serious bruising where the drug was injected, redness or pain.
Repatha was the second drug that has been approved and it is part of a new drug class more commonly known by doctors as PCSK9 inhibitors. It was approved only if it be used with diets that allow maximum statin toleration within adult patients. The adults usually have heterozygous familial hypercholesterolemia, homozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease.
All these diseases imply that the LDL cholesterol level be lowered if patients do not want to have any serious complications. Any type of familial hypercholesterolemia is a condition that is passed genetically and it causes extremely high levels of LDL cholesterol, for example. The high level of cholesterol is related to heart diseases.
Repatha is the antibody with the aim of locating PCSK9, a protein that eliminates receptors on the liver which are meant to remove LDL cholesterol form the bloodstream. If the PCSK9 is not able to perform its duty, then more receptors can develop on the liver, ensuring that cholesterol levels are down.
Repatha was not approved without tests, however. It underwent a 52-week placebo-controlled trial followed by another eight 12-week placebo-controlled trials. The trials were mostly conducted on patients. Hyperlipidemia, including specially-enrolled patients with familial hypercholesterolemia.
One of the 12-week trials had the aim of switching in between Repatha and placebo in order to see what treatment would be more beneficial for the patients. And it turned out that those consuming Repatha had an average LDL cholesterol reduction of around 60 percent.
However, despite the drawbacks that were mentioned earlier, Repatha can also cause allergic reactions. Some of the reports included rashes or hives. So if you are using Repatha and start experiencing any symptom that should occur, please visit your doctor immediately.
As far as specialists are concerned, Repatha is safe to use and can bring a great benefit to those who require a lower LDL cholesterol level in order to live a normal life.
Photo Credits medscape.com
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