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The US-based researchers have successfully generated a 3-D functional human stomach tissue in order to create miniature form of stomachs using stem cells called pluripotent in laboratory.
Notably, the human pluripotent stem cells (hPSCs) have the potential to transform into any type of cell in the body.
Principal study investigator Jim Wells, who is also a scientist at Cincinnati Children’s Hospital Medical Center, said, “No one had generated gastric cells from hPSCs ever before. Apart from this, we found how to promote formation of 3-D gastric tissue with complex architecture and cellular composition.”
According to the researchers, the first-time molecular generation of three dimensional human gastric organoids (hGOs) brings several new opportunities for discovery of new and effective drugs, modelling early stages of stomach cancer and examining the underpinnings of obesity related to diabetes.
Talking about the study’s findings, Wells underlined that the differences between the species in the embryonic development and architecture of the adult stomach contribute in making the mouse models below optimal for analyzing the development of human stomach and disease.
According to the researchers, the main step towards growing human gastric organoids was to spot the procedure involved in the formation of normal stomach formation during embryonic development.
The manipulation of these normal steps in a petri dish allowed the scientists to coax human pluripotent stem cells to convert into stomach cells.
Over the course of the study period, these procedures led to the formation of three dimensional human gastric organoids that were about 3 mm (1/10th of an inch) in diameter.
The study was detailed in the journal Nature.