A new study set out on the ambitious task of creating an exercise pill. The team behind it is hoping to offer people that are too ill or unable a proper chance at exercising. They may one day do so without training, by simply “convincing” their body to exercise with help from this pill.
The Salk team of scientists behind this new study carried out a series of mice trials. Their research results were released in the journal Cell Metabolism. The researchers have been testing the effects of their latest version of an exercise pill.
This Exercise Pill Already Has More Than One Effect
This is based on a chemical compound named GW1516. Working as an active ingredient, this compound can act on the PPARD. Previous studies showed that this gene could be linked to exercising. They also showed that mice with permanently activated PPARD are great “long-distance” runners.
Now, tests demonstrated that GW1516 could help by directly activating this gene. In turn, this made the tested mice better runners, even without previous training. Also, the exercise pill seemed to have a widespread effect. A high dose of GW1516 brought changes to 975 genes.
The effects also varied as genes that used carbohydrates were suppressed while the ones that help break down fats and encourage burning received a boost.
The research team tested the effects of it pill by splitting its trial mice into two groups. One was given the GW1516 boost, the control group was not, but both headed for the treadmill. There, the mice who got the pill were able to run almost 70 percent longer or for 270 minutes. The specimens that went without it only lasted some 160 minutes.
“Exercise activates PPARD, but we’re showing that you ca do the same thing without mechanical training. It means you can improve endurance […] without all the physical effort,” stated Weiwei Fan, one of the study authors.
More research will be needed to determine if the exercise pill will have similar results when used by humans. But the team has more work to do before it can test this theory. A long-term study will also have to deal with any potential side effects.
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